Chun-Tao Che
Harry H.S. Fong Professor of Pharmacognosy, College of Pharmacy
Director, WHO Collaborating Center for Traditional Medicine
Contact
Address:
833 South Wood St, Chicago, Illinois
Office Phone:
Email:
Related Sites:
About Heading link
Research Interests:
Drug lead discovery from medicinal plants; Traditional Chinese medicine; Quality and standardization of botanical supplements
Teaching and Supervision Heading link
Doctoral Research in Pharmacog (PMPG 599), 8/23/2021 – 12/3/2021
PhLAMES 5 (PHAR 469), 8/23/2021 – 12/3/2021
Doctoral Research in Pharmacog (PMPG 599), 1/11/2021 – 4/30/2021
PDAT 2: GI/Endocrine (PHAR 502), 1/11/2021 – 4/30/2021
PDAT 2: GI/Endocrine (PHAR 502), 1/11/2021 – 4/30/2021
PhLAMES 6 (PHAR 470), 1/11/2021 – 4/30/2021
Selected Grants
Medicinal Plants of Laos: Discoveries, Conservation, amd Community Engagement: Phase II, California Community Foundation., 7/1/2019 - 6/30/2022, Obligated Amount: $219090; Anticipated Amount: $219090
Medicinal Plants of Laos: Discoveries, Conservation, amd Community Engagement: Phase II, California Community Foundation., 7/1/2019 - 6/30/2022, Obligated Amount: $219090; Anticipated Amount: $219090
Defining the role of isoprenylated xanthones from the mangosteen for enhancing degradation of full length and variant forms of androgen receptor in prostate cancer, National Institutes of Health (National Cancer Institute)., 1/1/2019 - 12/31/2023, Obligated Amount: $1376358; Anticipated Amount: $1765131
Rosemary as a Food Preservative: Implications for Gastrointestinal Health, US Department of Agriculture (National Institute of Food and Agriculture)., 1/1/2017 - 4/14/2022, Obligated Amount: $470000; Anticipated Amount: $470000
California Community Foundation (CCF) Elina Vesara Ostern Fund, California Community Foundation., 7/1/2013 - 12/31/2014, Obligated Amount: $53804; Anticipated Amount: $53804
Technical Development of a Herb-based Topical Application for Psoriasis Treatment, Innovation and Technology Commission., 4/1/2007 - 9/30/2008, No Obligated Amount Set; No Anticipated Amount Set
Selected Publications
Tao, Weiwei, Wang, Neng, Ruan, Jie, Cheng, Xiaolan, Fan, Lu, Zhang, Pengfei, Lu, Cai, Hu, Yue, Che, Chuntao, Sun, Dongdong, Duan, Jinao, Zhao, Ming. (2022). Enhanced ROS-Boosted Phototherapy against Pancreatic Cancer via Nrf2-Mediated Stress-Defense Pathway Suppression and Ferroptosis Induction. ACS Applied Materials & Interfaces. doi:10.1021/acsami.1c22861.
Burton, Tristesse CJ, Lankin, David C, Nikolic, Dejan, Guo, Brian, Ju, Jianming, Dietz, Birgit M, Che, Chun-Tao, Soejarto, Djaja Djendoel, van Breemen, Richard B. (2021). Isolation and elucidation of two isoflavonoids from an American Indian plant, Amorpha canescens Pursh, using Magnetic Microbead Affinity Selection Screening (MagMASS) for estrogen receptor alpha ligands. Phytochemistry Letters, 45, 110-116. doi:10.1016/j.phytol.2021.07.018.
Dutta, Naibedya, Pemmaraju, Deepak Bharadwaj, Ghosh, Suvranil, Ali, Asif, Mondal, Ayan, Majumder, Chirantan, Nelson, Vinod K, Mandal, Subhash C, Misra, Anup K, Rengan, Aravind K, Ravichandiran, Velyutham, Che, Chun-Tao, Gurova, Katerina V, Gudkov, Andrei V, Pal, Mahadeb. (2021). Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways. Journal of Ethnopharmacology, 283, 114666. doi:10.1016/j.jep.2021.114666.
Rice, Amy J, Pesavento, Russell P, Ren, Jinhong, Youn, Isoo, Kwon, Youngjin, Ellepola, Kassapa, Che, Chun-Tao, Johnson, Michael E, Lee, Hyun. (2021). Identification of Small Molecule Inhibitors against Staphylococcus aureus Dihydroorotase via HTS. International Journal of Molecular Sciences, 22, (18), 9984. doi:10.3390/ijms22189984.
Zhang, Pengfei, Tao, Weiwei, Lu, Cai, Fan, Lu, Jiang, Qihang, Yang, Chengbin, Shang, Erxin, Cheng, Haibo, Che, Chuntao, Duan, Jinao, Zhao, Ming. (2021). Bruceine A induces cell growth inhibition and apoptosis through PFKFB4/GSK3β signaling in pancreatic cancer.. Pharmacol Res, 169, 105658. doi:10.1016/j.phrs.2021.105658.
Xu, Ming-Ming, Zhou, Junfei, Zeng, Liping, Xu, Jingchen, Onakpa, Monday M, Duan, Jin-Ao, Che, Chun-Tao, Bi, Hongkai, Zhao, Ming. (2021). Pimarane-derived diterpenoids with anti- Helicobacter pylori activity from the tuber of Icacina trichantha. Organic Chemistry Frontiers, 8, (12), 3014-3022. doi:10.1039/d1qo00374g.
Lu, Cai, Fan, Lu, Zhang, Peng-Fei, Tao, Wei-Wei, Yang, Cheng-Bin, Shang, Er-Xin, Chen, Fei-Yan, Che, Chun-Tao, Cheng, Hai-Bo, Duan, Jin-Ao, Zhao, Ming. (2021). A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity. Computational and Structural Biotechnology Journal, 19, 3437-3450. doi:10.1016/j.csbj.2021.06.011.
Huang, Ya-Ping, Zhao, Yuan-Yu, Johnson, Oluwatosin O, Zhang, Jian, Zhao, Ming, Che, Chun-Tao, Yin, Zhi-Qi. (2021). Further prenylated anthranoids from Harungana madagascariensis.. Phytochemistry, 186, 112711. doi:10.1016/j.phytochem.2021.112711.
Sun, Meng, Guo, Brian, Xu, Mingming, Zhao, Ming, Onakpa, Monday M, Wu, Zhenlong, Burdette, Joanna E, Che, Chun-Tao. (2021). (9βH)- and 17-Nor-Pimaranes from Icacina oliviformis.. J Nat Prod, 84, (4), 949-955. doi:10.1021/acs.jnatprod.9b01131.
Education
Degrees:
B.S., The Chinese University of Hong Kong, Hong Kong, 1975
M.Phil., The Chinese University of Hong Kong, Hong Kong, 1977
Ph.D., University of Illinois at Chicago, United States, 1982
Postgraduate Training:
Postdoctoral Chemist, Ludwig Institute for Cancer Research, Canada, 1983
Selected Presentations
Warpeha, Katherine, Thnaibat, Nayfah, Che, Chun-Tao, Park, Thomas. (2018 September 01). Phenylalanine Boosts Brassica Production of Polyphenols for Medicinal Production.