Bernard Santarsiero
Research Professor, Department of Pharmaceutical Sciences; Affiliate, Pharmacognosy Institute
Research Professor, Department of Pharmaceutical Sciences
Affiliate, Pharmacognosy Institute
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My expertise is at the interface between structural chemistry and structural biology with a long-term research objective to foster and develop all aspects of drug discovery, including target selection, robotics, high-throughput screening, assay development, and computational methodologies. Focusing on human health, I have collaborated or led projects addressing infectious and neurodegenerative disease, natural products, cancer chemoprevention, and diabetes. As a co-founder of a small drug discovery company, Syrrx, and founding group leader of the Novartis Institute for Functional Genomics, we developed two new drugs, alogliptin and pioglitazone. More recently, over the past decade, I have been on leadership teams that seek to reduce the equity gaps of students of color in higher education, and have helped to develop a number of new programs at UIC, e.g., L@s GANAS, DuSable Scholars, PBRC-PREP.
Selected Grants
Driving Change Learning Grant 2021, Hughes (Howard) Medical Inst., 4/1/2021 - 3/31/2023, Obligated Amount: $50000; Anticipated Amount: $50000
Interventions to Improve Student Success through the American Opportunity Tax Credit at UIC, US General Services Administration., 8/19/2019 - 8/18/2020, Obligated Amount: $1411; Anticipated Amount: $1411
UIC Portal for Biomedical Research Careers (UIC PBRC) PREP, National Institutes of Health (National Institute of General Medical Sciences)., 1/1/2018 - 12/31/2022, Obligated Amount: $1409395; Anticipated Amount: $1512419
HSI STEM Grant: Increasing Latin@s Access to Networks for Advancement in Science, US Department of Education., 10/1/2016 - 9/30/2022, Obligated Amount: $5445211; Anticipated Amount: $5445211
Center for Natural Product Technologies at UIC, National Institutes of Health (National Center for Complementary and Integrative Health)., 9/1/2015 - 6/30/2020, Obligated Amount: $1456875; Anticipated Amount: $1456875
Cyber-Enabled Instrumentation Strategic Planning Workshop, Directorate for Mathematical & Physical Sciences., 4/15/2008 - 3/31/2009, Obligated Amount: $23500; No Anticipated Amount Set
Novel Therapeutics for Bacillus Anthracis, National Institutes of Health (National Institute of Allergy and Infectious Diseases)., 8/15/2003 - 1/31/2009, Obligated Amount: $15456716; Anticipated Amount: $15456716
An Undulator Resource for Structural Biology, National Center for Advancing Translational Sciences., 6/15/2001 - 3/31/2013, Obligated Amount: $28175830; No Anticipated Amount Set
Selected Publications
Argade, Malaika D, Straub, Carolyn J, Rusali, Lisa E, Santarsiero, Bernard D, Riley, Andrew P. (2021). Synthesis of Aristoquinoline Enantiomers and Their Evaluation at the α3β4 Nicotinic Acetylcholine Receptor. Organic Letters, 23, (20), 7693-7697. doi:10.1021/acs.orglett.1c02057.
Ghosh, Dibbendu, Sinhababu, Soumen, Santarsiero, Bernard D, Mankad, Neal P. (2020). A W/Cu Synthetic Model for the Mo/Cu Cofactor of Aerobic CODH Indicates That Biochemical CO Oxidation Requires a Frustrated Lewis Acid/Base Pair. Journal of the American Chemical Society, 142, (29), 12635-12642. doi:10.1021/jacs.0c03343.
Zhou, Bin, Shetye, Gauri, Yu, Yang, Santarsiero, Bernard D, Klein, Larry L, Abad-Zapatero, Cele, Wolf, Nina M, Cheng, Jinhua, Jin, Yingyu, Lee, Hanki, Suh, Joo-Won, Lee, Hyun, Bisson, Jonathan, McAlpine, James B, Chen, Shao-Nong, Cho, Sang-Hyun, Franzblau, Scott G, Pauli, Guido F. (2020). Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502. Journal of Natural Products, 83, (3), 657-667. doi:10.1021/acs.jnatprod.9b01095.
Wolf, Nina M, Lee, Hyun, Choules, Mary P, Pauli, Guido F, Phansalkar, Rasika, Anderson, Jeffrey R, Gao, Wei, Ren, Jinhong, Santarsiero, Bernard D, Lee, Hanki, Cheng, Jinhua, Jin, Ying-Yu, Ho, Ngoc Anh, Duc, Nguyen Minh, Suh, Joo-Won, Abad-Zapatero, Celerino, Cho, Sanghyun. (2019). High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads. ACS Infectious Diseases, 5, (6), 829-840. doi:10.1021/acsinfecdis.8b00276.
Waldhart, Greyson W, Mankad, Neal P, Santarsiero, Bernard D. (2018). Correction to Improvements to Practical Usability of the “Crystalline Sponge” Method for Organic Structure Determination. Organic Letters, 20, (12), 3714-3714. doi:10.1021/acs.orglett.8b01553.
May, Daniel S, Kang, Hahk-Soo, Santarsiero, Bernard D, Krunic, Aleksej, Shen, Qi, Burdette, Joanna E, Swanson, Steven M, Orjala, Jimmy. (2018). Ribocyclophanes A–E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria. Journal of Natural Products, 81, (3), 572-578. doi:10.1021/acs.jnatprod.7b00954.
Hevener, Kirk E, Santarsiero, Bernard D, Lee, Hyun, Jones, Jesse A, Boci, Teuta, Johnson, Michael E, Mehboob, Shahila. (2018). Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK). Acta Crystallographica Section F: Structural Biology Communications, 74, (2), 105-112. doi:10.1107/s2053230x18000262.
Santarsiero, BD. (2017). Richard E. Marsh (1922–2017). Acta Crystallographica Section C: Structural Chemistry, 73, (12), 1038-1039. doi:10.1107/s2053229617017090.
Zhou, Fei, Liu, Sheng, Santarsiero, Bernard D, Wink, Donald J, Boudinet, Damien, Facchetti, Antonio, Driver, Tom. (2017). Synthesis and Properties of New N‐Heteroheptacenes for Solution‐Based Organic Field Effect Transistors. Chemistry – A European Journal, 23, (51), 12542-12549. doi:10.1002/chem.201701966.
Education
PhD (1980) University of Washington