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Glycyrrhiza spp. (Licorice) | Botanial Profile

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Review & More General Articles on Glycyrrhiza glabra, G. uralensis, and G. inflata (Licorice) by the UIC Botanical Center


With direct DOI links to the original articles.

van Breemen RB. Development of Safe and Effective Botanical Dietary Supplements. J Med Chem. 2015, 58(21), 8360-72.

Simmler C, Chen SN, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF. Botanical Integrity: Part 2: Traditional and Modern Analytical Approaches. HerbalGram. 2016 Spring; 109:60-64.

Bolton JL. Menopausal Hormone Therapy, Age, and Chronic Diseases: Perspectives on Statistical Trends. Chem Res Toxicol. 2016, 29(10), 1583-1590.

Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women’s Health. Pharmacol Rev. 2016, 68(4), 1026-1073.

Peer-reviewed Publications on Glycyrrhiza glabra, G. uralensis, and G. inflata (Licorice) by the UIC Botanical Center


Total number of publications on this botanical: 25

With direct DOI links to the original articles.

Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001, 49(5), 2472-9.

Xu H, Fabricant DS, Piersen CE, Bolton JL, Pezzuto JM, Fong H, Totura S, Farnsworth NR, Constantinou AI. A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women’s health. Phytomedicine. 2002, 9(8), 757-62.

van Breemen RB, Fong HH, Farnsworth NR. The role of quality assurance and standardization in the safety of botanical dietary supplements. Chem Res Toxicol. 2007, 20(4), 577-82.

Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Comb Chem High Throughput Screen. 2008, 11(4), 283-93.

Dietz BM, Bolton JL. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chem Biol Interact. 2011, 192(1-2), 72-80.

Hu C, Nikolic D, Eggler AL, Mesecar AD, van Breemen RB. Screening for natural chemoprevention agents that modify human Keap1. Anal Biochem. 2012, 421(1), 108-14.

Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen SN, Pauli GF. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. J Agric Food Chem. 2013, 61(9), 2146-57.

Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med. 2013, 79(7), 538-53.

Simmler C, Fronczek FR, Pauli GF, Santarsiero BD. Absolute configuration of naturally occurring glabridin. Acta Crystallogr C. 2013, 69(Pt 11), 1212-6.

Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. PLoS One. 2013, 8(7), e67947.

Simmler C, Pauli GF, Chen SN. Phytochemistry and biological properties of glabridin. Fitoterapia. 2013, 90, 160-84.

Simmler C, Jones T, Anderson JR, Nikolić DC, van Breemen RB, Soejarto DD, Chen SN, Pauli GF. Species-specific Standardisation of Licorice by Metabolomic Profiling of Flavanones and Chalcones. Phytochem Anal. 2014, 25(4), 378-88.

Simmler C, Nikolić D, Lankin DC, Yu Y, Friesen JB, van Breemen RB, Lecomte A, Le Quémener C, Audo G, Pauli GF. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice. J Nat Prod. 2014, 77(8), 1806-16.

Simmler C, Anderson JR, Gauthier L, Lankin DC, McAlpine JB, Chen SN, Pauli GF. Metabolite Profiling and Classification of DNA-Authenticated Licorice Botanicals. J Nat Prod. 2015, 78(8), 2007-22.

Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL. Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It. Chem Res Toxicol. 2015, 28(8), 1584-94.

Li G, Huang K, Nikolic D, van Breemen RB. High-Throughput Cytochrome P450 Cocktail Inhibition Assay for Assessing Drug-Drug and Drug-Botanical Interactions. Drug Metab Dispos. 2015, 43(11), 1670-8.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolić D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women’s Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. Chem Res Toxicol. 2015, 28(11), 2130-41.

Li G, Nikolic D, van Breemen RB. Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS. J Agric Food Chem. 2016, 64(42), 8062-8070.

Simmler C, Lankin DC, Nikolić D, van Breemen RB, Pauli GF. Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A. Fitoterapia. 2017, 121, 6-15.

Li G, Simmler C, Chen L, Nikolic D, Chen SN, Pauli GF, van Breemen RB. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. Eur J Pharm Sci. 2017, 109:182-190.

Huang L, Nikolic D, van Breemen RB. Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2017, 409(30), 6937-6948.

Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen SN, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. J Nat Prod. 2018, 81(4), 966-975.

Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. inflata Extracts Modulate Estrogen Metabolism in ACI Rats. Cancer Prev Res (Phila). 2018, 11(12), 819-830.

Yu Y, Pauli GF, Huang L, Gan LS, van Breemen RB, Li D, McAlpine JB, Lankin DC, Chen SN. Classification of Flavonoid Metabolomes via Data Mining and Quantification of Hydroxyl NMR Signals. Anal Chem. 2020, 92(7), 4954-4962.

Mbachu OC, Howell C, Simmler C, Malca Garcia GR, Skowron KJ, Dong H, Ellis SG, Hitzman RT, Hajirahimkhan A, Chen SN, Nikolic D, Moore TW, Vollmer G, Pauli GF, Bolton JL, Dietz BM. SAR Study on Estrogen Receptor α/β Activity of (Iso)flavonoids: Importance of Prenylation, C-Ring (Un)Saturation, and Hydroxyl Substituents. J Agric Food Chem. 2020, 68(39), 10651-10663.