Actaea racemosa (Black Cohosh) | Botanical Profile

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Review & More General Articles on Actaea racemosa (Black Cohosh) by the UIC Botanical Center

With direct DOI links to the original articles.

Piersen CE. Phytoestrogens in botanical dietary supplements: implications for cancer. Integr Cancer Ther. 2003, 2(2), 120-38.

Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women’s Health: from plant to clinical use. Am J Clin Nutr. 2008, 87(2), 504S-8S.

Qiu, F.; McAlpine, J. B.; Krause, E. C.; Chen, S.-N.; Pauli, G. F. Pharmacognosy of Black Cohosh: The Phytochemical and Biological Profile of a Major Botanical Dietary Supplement.; Progress in the Chemistry of Organic Natural Products (“Zechmeister”); Springer: Vienna/New York, 2014; Vol. 99, 1-68.

Nikolić D, Lankin DC, Cisowska T, Chen SN, Pauli GF, van Breemen RB. Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities. In The Formation, Structure and Activity of Phytochemicals. Recent Advances in Phytochemistry,  Springer, Cham. 2015, Vol 45, 31-75.

Peer-reviewed Publications on Actaea racemosa (Black Cohosh) by the UIC Botanical Center

Total number of publications on this botanical: 30

With direct DOI links to the original articles.

Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001, 49(5), 2472-9.

Chen SN, Li W, Fabricant DS, Santarsiero BD, Mesecar A, Fitzloff JF, Fong HH, Farnsworth NR. Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. J Nat Prod. 2002, 65(4), 601-5.

Li, W.; Chen, S.; Fabricant, D.; Angerhofer, C. K.; Fong, H. H.; Farnsworth, N. R.; Fitzloff, J. F. High-Performance Liquid Chromatographic Analysis of Black Cohosh (Cimicifuga Racemosa) Constituents with in-Line Evaporative Light Scattering and Photodiode Array Detection. Anal. Chim. Acta 2002, 471(1), 61–75.

Chen SN, Fabricant DS, Lu ZZ, Fong HH, Farnsworth NR. Cimiracemosides I-P, new 9,19-cyclolanostane triterpene glycosides from Cimicifuga racemosa. J Nat Prod. 2002, 65(10), 1391-7.

Chen SN, Fabricant DS, Lu ZZ, Zhang H, Fong HH, Farnsworth NR. Cimiracemates A-D, phenylpropanoid esters from the rhizomes of Cimicifuga racemosa. Phytochemistry. 2002, 61(4), 409-13.

Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworth NR, Constantinou AI, Van Breemen RB, Pezzuto JM, Bolton JL. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. J Agric Food Chem. 2002, 50(24), 7022-8.

Xu H, Fabricant DS, Piersen CE, Bolton JL, Pezzuto JM, Fong H, Totura S, Farnsworth NR, Constantinou AI. A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women’s health. Phytomedicine. 2002, 9(8), 757-62.

Johnson BM, van Breemen RB. In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh). Chem Res Toxicol. 2003, 16(7), 838-46.

Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. J Agric Food Chem. 2003, 51(19), 5661-70.

Li W, Sun Y, Liang W, Fitzloff JF, van Breemen RB. Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2003,17(9), 978-82.

Chen SN, Fabricant DS, Pauli GF, Fong HH, Farnsworth NR. Synthesis of cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa. Nat Prod Res. 2005, 19(3), 287-90.

Fabricant DS, Nikolic D, Lankin DC, Chen SN, Jaki BU, Krunic A, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa. J Nat Prod. 2005, 68(8), 1266-70.

He K, Pauli GF, Zheng B, Wang H, Bai N, Peng T, Roller M, Zheng Q. Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products. J Chromatogr A. 2006, 1112(1-2), 241-54.

Rhyu MR, Lu J, Webster DE, Fabricant DS, Farnsworth NR, Wang ZJ. Black cohosh (Actaea racemosa, Cimicifuga racemosa) behaves as a mixed competitive ligand and partial agonist at the human mu opiate receptor. J Agric Food Chem. 2006, 54(26), 9852-7.

Chen SN, Lankin DC, Nikolic D, Fabricant DS, Lu ZZ, Ramirez B, van Breemen RB, Fong HH, Farnsworth NR, Pauli GF. Chlorination diversifies Cimicifuga racemosa triterpene glycosides. J Nat Prod. 2007, 70(6), 1016-23.

Qiu SX, Dan C, Ding LS, Peng S, Chen SN, Farnsworth NR, Nolta J, Gross ML, Zhou P. A triterpene glycoside from black cohosh that inhibits osteoclastogenesis by modulating RANKL and TNFalpha signaling pathways. Chem Biol. 2007, 14(7), 860-9.

Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Comb Chem High Throughput Screen. 2008, 11(4), 283-93.

Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. J Agric Food Chem. 2008, 56(24), 11718-26.

Gödecke T, Lankin DC, Nikolic D, Chen SN, van Breemen RB, Farnsworth NR, Pauli GF. Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa). J Nat Prod. 2009, 72(3), 433-7.

Gödecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochem Anal. 2009, 20(2), 120-33.

Huang Y, Jiang B, Nuntanakorn P, Kennelly EJ, Shord S, Lawal TO, Mahady GB. Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitro. Curr Drug Saf. 2010, 5(2), 118-24.

Li J, Gödecke T, Chen SN, Imai A, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Nikolić D. In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4. Xenobiotica. 2011, 41(12), 1021-1030.

Qiu F, Imai A, McAlpine JB, Lankin DC, Burton I, Karakach T, Farnsworth NR, Chen SN, Pauli GF. Dereplication, residual complexity, and rational naming: the case of the Actaea triterpenes. J Nat Prod. 2012, 75(3), 432-43.

Nikolić D, Gödecke T, Chen SN, White J, Lankin DC, Pauli GF, van Breemen RB. Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.). Fitoterapia. 2012, 83(3), 441-60.

Qiu F, McAlpine JB, Lankin DC, Burton I, Karakach T, Chen SN, Pauli GF. 2D NMR barcoding and differential analysis of complex mixtures for chemical identification: the Actaea triterpenes. Anal Chem. 2014, 86(8), 3964-72.

Nikolić D, Li J, van Breemen RB. Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes. Biomed Chromatogr. 2014, 28(12), 1647-51.

Imai A, Lankin DC, Nikolić D, Ahn S, van Breemen RB, Farnsworth NR, McAlpine JB, Chen SN, Pauli GF. Cycloartane Triterpenes from the Aerial Parts of Actaea racemosa. J Nat Prod. 2016, 79(3), 541-54.

Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women’s Health. Pharmacol Rev. 2016, 68(4), 1026-1073.

Imai A, Lankin DC, Gödecke T, Chen SN, Pauli GF. NMR based quantitation of cycloartane triterpenes in black cohosh extracts. Fitoterapia. 2020, 141:104467.

Imai A, Lankin DC, Gödecke T, Chen SN, Pauli GF. Differentiation of Actaea species by NMR metabolomics analysis. Fitoterapia. 2020,146:104686.