Quantitative NMR (qNMR)
Quantitative NMR (qNMR) | Metrology-grade Analysis for Natural Products and Pharmaceuticals
qNMR – The Mag[net]ic Research Tool
Nuclear Magnetic Resonance (NMR) is a powerful spectroscopic tool that is widely used in structural analysis. While the majority of NMR applications is qualitative, quantitative NMR (qNMR) represents a metrological method of analysis with unique capabilites.
qHNMR – The Purity Assay
As protons/hydrogens are nearly ubiquitous in organic molecules, the 1H variant of qNMR, qHNMR, has great potential to serve as universal and precise purity assay for synthetic and natural compounds, thereby surpassing the capabilities of (HP)LC-based methods.
- qNMR Perspectives Article in the Journal of Medicinal Chemistry on purity and qHNMR Assays (J. Med. Chem. 2014, 57, 9220; DOI:10.1021/jm500734a; Open Access)
- Supporting Information includes examples and the raw NMR data that enables reader to follow the presented calculations and also perform their own based on the given examples
- Youtube Video by CypressEcho521, explaining the qNMR concepts from the 2014 J. Med. Chem. article in other words and with slides
- Practical qNMR Support: Spreadsheets for qHNMR calculations (ZIP files containing ODS and XLSX files)